Dual channel question.

Currently I've got two 2GB sticks of DDR3 RAM. I've got two free RAM slots. Let's say I get two more sticks of a different size and speed (still DDR3 of course) than my current 2GB sticks. Does this screw up dual channel in any way and/or is it at all inferior to having all four sticks being of the same brand, size, and speed?

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